Bodybuilding And Steroids

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Mechano Growth Factor MGF

Let’s start with an explanation of Mechano Growth Factor (MGF) and what it does. The muscle insulin-like growth factor-I (IGF-I) mRNA splice variant (IGF-IEc) has been identified in rodents. IGF-IEc, also called mechano growth factor (MGF) has been found to be up-regulated by exercise or muscle damage. Growth hormone (GH) is the principal regulator of IGF-I expression in several tissues including the skeletal muscle.

MGF is derived from IGF-I but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibres that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms.

The C-terminal peptide MGF, an alternatively spliced variant IGF-1, was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. MGF is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle.

The physiological function of MGF was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

Ok, enough of the science. I am sure your brain is probably hurting after reading that, I know mine was. In really simple terms, MGF is a variant of IGF-1, an isoform that is particularly sensitive to muscle trauma (weight training) and is essential for repair and growth of new cells, similar in manner to IGF-1. What you need to know is MGF triggers new cell growth or hyperplasia in rat testing, and since we as bodybuilders fancy ourselves as lab rats, it is currently the in vogue peptide by top amateurs and pro’s.

Well all of this sounds great but what is the catch? This is where we reach a cross-road, a potential problem with MGF. As great as MGF has been in clinical trials and rat studies, the fact is that injected MGF has a half life of minutes’.yes minutes. So how are you going to make this work, besides injecting every hour or so of your waking day? The answer lies in a little known molecule protection agent knows as PEGylation.

So what is or PEGylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell. Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or wax-like in consistency and are soluble in water and in many organic solvents.

Polyethylene glycol itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG.

PEGylation can improve dosing convenience of many small molecules by increasing bioavailability and reducing dosing frequency. PEGylation also increases the amount of time the cell sits at the target site. This can be both good and bad. It is good because it increases the drug concentration, and with a longer time at the site, there is more chance of uptake by the cell. The bad news is that while it is sitting at the cell, there is increased risk of damage by enzymes that attack the cell. This is a double-edge sword that is a necessary evil; you must protect the molecule but at the same time increase the risk factor of damage due to longer exposure times at the target cell. As a result of the increased time at the cell, the optimal drug concentration can be achieved with less frequent dosing; a significant benefit to bodybuilders who are usually using poly-pharmacy at its finest.

PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells. While this thinking is optimistic at best, there is no research that would support site specific injections being beneficial for localized growth. This is a myth that has purveyed aas and peptide use for years. At this time, the literature and lab studies support subcutaneous injection, using small gauge insulin syringes.

Obviously there are no human research trials at this time; the peptide is still in research phases. Bodybuilder use at this time is all by trial and error. One company that currently carries MGF has conducted their own research trials, using test participants from underground steroid boards who are providing feedback in weekly intervals. While this is hardly a controlled environment and may have to many variables to accurately assess the product, at least it is a start.

I have also been conducting my own research, on myself and my clients, who often refer to themselves as Gavin’s guinea pigs. As with most peptides, more is not better. Smaller doses with less frequent injection schedules have proven to be optimal. I personally have been using 200mcg injected sub-q, two times per week. I have had my clients try 100mcg, two times per week, three times per week, daily, etc. So far the best results have been my personal method, 200mcg, two times per week.

Elite athletes are experiencing incredible body fat loss, increased pumps, fullness, and vascularity. I was able to gain 6 pounds of lean mass and lose 4.2% body fat in 4 weeks of use. I kept using it for weeks 5 and 6 but with no further gains or body fat loss. It seems that MGF stalls out at the 4 week mark, my theory being that much like with media grade IGF-1 LR3, the cells reach super saturation and cannot process any further uptake of the peptide sequence. It is possible to bypass this saturation, but it will take some time to work out the differential nature of the timing, much like I had to do with IGF-1 LR3, where I have now found ways to take it for up to 20 weeks with little to no cell down-regulation.

At this time all use and injection schedules are by word of mouth, sometimes by erroneous information on underground boards. Proper use of MGF is merely by speculation; it will take some time to sort out the best method of administration, although with the ever changing world of science, where nothing ever stands still, it may take years to sort out optimal dosing schedules. Even with such stable peptide structures as growth hormone that have had years of research, new information is always being studied, and I speculate that it will with all peptides.

Primobolan Methenolone-Enanthate and Methenolone-Acetate

Primobolan is one of the few steroids that can regularly be found in both oral and injectable forms; Methenolone-Enanthate being the injectable and Methenolone-Acetate the oral. A once fairly popular anabolic steroid, Primobolan is not nearly as popular as it once was; however, due to rumors surrounding Arnold Schwarzenegger implying it was his favorite, to this day there remains a strong almost cult like following. While there is no question, Primobolan is one of the safer steroids we can use in-terms of side-effects because Masteron is more readily available and far less counterfeited many in recent years have opted for that rout.

As a very mild DHT steroid, most will not see any bulking benefits from its use as it does not possess traits apt for this purpose. You could use this steroid as part of a bulking cycle but it would necessarily require massive amounts and due to this steroid being outrageously expensive this is simply not feasible. Most will find Primobolan to be best served in a cutting cycle; while it will not promote muscle tissue growth to any great degree it is a fantastic steroid for the use of preserving existing muscle tissue. Further, as it can preserve it has also been shown to be one of the few anabolic steroids that can directly lead to fat-loss. While almost all anabolic steroids carry this fat loss trait to a degree, Primobolan appears to do so in a more direct manner.

Without question the greatest benefit to Primobolan use lies within its safe nature when taken by female anabolic steroid users. Make no mistake, this is not a girl only steroid but because so many steroids are so harsh on females, as steroids such as Primo and Anavar are generally well-tolerated by women they hold somewhat of a special place. The largest concern for most women and anabolic steroid use is virilization; however, with responsible use this is non-existent in almost all females. While it can occur, if symptoms start to show, simply discontinuing will see them fade away. This makes Primobolan very beneficial to females as they are able to enjoy a moderate anabolic affect without the nasty side-effects. It is however very important to note, if virilization effects set in there is often no turning back; don’t push the envelope.

Primobolan Cycles & Doses:
Because Primobolan is a very weak steroid most men will necessarily need to take in quite a bit to really see any effect. Many men who use Primobolan are often very disappointed simply because they didn’t use enough. Further, men who take oral Primobolan are often left even more disappointed as it takes an even larger amount of the oral version to reap the same benefits as the injectable version. Most men will find 500mg per week to be the necessary dose to truly see any positive result(s) and because of its mild nature 8 weeks of use will be the minimum with 12 weeks being for more optimal.

For our female athlete either version will create a great boost but of course injectable will prove to be far more efficient. To ensure virilization does not occur most women will need to use Primobolan in 4-6 week bursts. For example, 4 weeks of use, followed by a two week break, followed by 4 weeks of use if desired; however, if virilization begins to show, no matter which week you’re in, stop use immediately and let your body heal. Most women will find 100mg per week to be a very powerful dose that brings them all they’d ever want or need with many finding 50mg to be efficient and effective.

Oct 1

The Benefits of Deca-Durabolin

Deca-Durabolin is a Nandrolone based steroid attached to the Decanoate ester with immense power due to its intrinsic properties. While there are many Nandrolone forms Nandrolone-Decanoate is the most common form among anabolic steroid users and it is the form known as Deca-Durabolin that most associate with the compound as that is the label name Organon gave its product. As Organon is one of the oldest and most respected human pharmaceutical companies all Nandrolone-Decanoate is commonly referred to as Deca-Durabolin. To fully understand this hormonal compound we only need to understand the active hormone Nandrolone and how the long ester Decanoate affects its release and mode of action. By understanding both aspects we can fully understand its benefits, how it effects the body and how best to supplement with use.

The benefits of Deca-Durabolin are very simple but as this is a very powerful anabolic they are very great. By understanding what Nandrolone does understanding the benefits of Deca-Durabolin should be fairly simple; increased muscle mass and increased strength. While these are the two most prominent effects there is the added benefit of joint relief as well by means of a secondary nature; for this reason many athletes will supplement with Deca-Durabolin even when not in a gaining phase in order to obtain such relief.

To give you an idea of how powerful this hormone is even small therapeutic doses can cause large increases in weight by increasing lean mass and this is achieved largely due to its nitrogen retention abilities. Those who supplement with Deca-Durabolin will find their muscle holds a far greater amount of nitrogen than without; as we understand being in a state of positive nitrogen retention is highly anabolic. This state of being can lead to vast although slow increases in muscle tissue and while that can lead to mass, coupled with increased collagen synthesis we experience a nice buildup in strength as well. Of equal importance if not even greater is the effect Nandrolone has on the production of IGF 1, a very powerful anabolic hormone in its own right belonging to the peptide class. While these potent anabolic qualities are very apt towards building mass and increasing strength they prove due to their action to readily promote a greater metabolic rate; this simply means we are able to build a larger, yet leaner and more powerful physique; as you can see Nandrolone is one amazing hormone.

Effects of Anavar

The effects of Anavar are quite welcomed by most performance enhancing athletes. The Oxandrolone hormone that is Anavar is one of the mildest anabolic steroids on the market, very side-effect friendly and generally well-tolerated by both men and women. In-fact, it is so well-tolerated by women, and so effective in female athletes, many have labeled Anavar as the girl steroid. In many ways, this is a very appropriate label, as the effects of Anavar are largely responsible for how we view fit females today. Many of your favorite female physique athletes, from bodybuilders, to figure and fitness and even bikini supplement with the Oxandrolone hormone, but it does not end there, not by a long shot. The fitness models you see advertising your favorite protein bar, you bet, they’re benefiting from the effects of Anavar. Then we have the starlets of the silver screen, it’s not uncommon for those who stay in fantastic shape to be supplementing with such mild anabolic steroids. In short, the Oxandrolone hormone has transformed the female physique as we know it today.

Of course, as this is such a beneficial hormone to women, the most obvious question is what about men? Men can absolutely benefit from the effects of Anavar; however, it’s simply not as efficient of a steroid for a few reasons. To begin, it will do almost nothing in-terms of promoting mass to any significant degree for a man. Further, it is one of the more expensive steroids on a per milligram basis, and by this fact can get very expensive since men will require five to almost ten times the amount depending on the man. Make no mistake, this can be an excellent steroid for a man to use when cutting, as the effects of Anavar will lend to a more pleasing physique.
The Beneficial Effects of Anavar

The beneficial effects of Anavar can largely be summed up by examining what the hormone can provide during a cutting style cycle. When calories are restricted, it can lead to a much more pleasing physique in the mirror for several reasons. When we diet, muscle tissue is often lost, and the Oxandrolone hormone can significantly protect it. Some tissue may still be lost, but you will preserve much more of it with Anavar in play. Further, by its nature, the effects of Anavar will promote a harder body, as well as an enhanced metabolic rate, and this is where the steroid truly shines through. While it will promote a greater metabolic rate, there is something fundamental to note regarding a hardening effect. Anavar will not make a fat physique hard; if you want to benefit from the total effects of Anavar you must already be somewhat lean. Most women will need to be under 20% body-fat, with below 15% being optimal, while most men will need to be under 10% body-fat with below 7% being optimal.
The Adverse Effects of Anavar

The adverse effects of Anavar are very few and exceedingly mild. For the female user, the number one concern is virilization; as such effects can destroy her femininity. However, there is some extremely good news, as the odds of virilization are very low when women supplement responsibly. If doses get too high you will fall prey, and unfortunately, even with low doses some women will find their genetic disposition does not allow them to tolerate the hormone. If such effects should occur you are encouraged to discontinue use immediately, for if you don’t they may become permanent.

As for men, there is a risk of hair-loss and acne, but the odds are in your favor. If you lose any hair, it will only happen if you are predisposed to male-pattern baldness. If you’re not predisposed, you will not lose the first hair. As for acne, only those who are extremely sensitive to acne will have a problem; even so, as this is such a mild steroid very few will fall prey. Beyond acne and hair-loss, there is the issue of testosterone suppression. It is a common misconception by many male performance enhancers that Oxandrolone does not suppress testosterone; they are dead wrong. However, it will suppress it far less than most steroids, but even so, some testosterone should be applied in exogenous form. If you supplement with testosterone when supplementing with Anavar, the testosterone suppression will be of no concern.

Post Injection Pain: The Causes And When To Worry

There are 3 causes of injection pain.


1) Tissue Irritation
This is probably the most likely cause of post injection pain and the least serious. Tissue irritation is likely to start 12-24 hours after injection, pain can be mild to moderate depending on the level of tissue irritation and the volume injected. The injection site is likely to swell within the muscle, maybe red and likely to be warm and very firm to the touch. The pain and swelling will start to fade after 72 hours and can last over a week in the worst cases. The most likely causes of tissue irritation are:

The steroid hormone crashes out of the solution in the depot. This causes crystallisation of the steroid hormone, this in turn places a lot of pressure on the nerve endings in the muscle belly causing knotting, swelling and pain - this is most common in long chain esters, high mg/ml concentration anabolic steroids and steroids compounded with less than idea oil blends.
A reaction to the acid compounds within the ester. With the metabolic breakdown of the ester attached to the hormone free form acids are released which can cause the muscle tissue rapid irritation at the injection site – this is most common with propionic acid of the propionate ester. Poor quality raw materials also liberate more freeform acids.

Excessive preservative. If too much benzyl Alcohol is used to formulate the solution inflammation and pain may result. Pharma grade usually contains 0.9% Benzyl alcohol where the common senseu states UGL products contain on average 2%. Anything above 1.2% offers no added anti-microbial effects. Due to water soluable nature of benzyl alcohol tissue irritation of this nature has been known to “travel” as the excessive alcohol disperses via the blood stream. This is most common with injection into the quads (vastus lateralis).The pain travels down toward the knee. This may however be in part due to lymphatic drainage and leads me nicely to my next point.

Ice and ibuprofen may help with the swelling. Hot baths, showers and massage of the injection site may help to distribute the injection and reduce pain.

2) Hitting the lymphatic system.
Hitting the lymphatic system is very rare. The lymphatic system is as vast as the circulatory system but the standard injection sights (Glute, ventro-glute, medial delts and vastus lateralis) are generally void of lymphatic nodes. If a lymph node is hit with an injection pain is likely to be severe and edema vast. The swelling will come on very fast and be extensive. It is also likely to “travel” along the lymph system to the next lymph gland. This is most noticeable with a vastus lateralis shot where the swelling tracks down toward the back of the knee. Unlike the edema experienced with tissue irritation (within the muscle only) the edema with a lymphatic puncture will be both inter and intra-muscular with a moderate amount of swelling just underneath the skin giving it a softer puffy feel. This can be tested for by pressing the swollen area with your finger, if in indent remains you have a more systematic edema and more than just local tissue irreation. The other most noticeable difference is that the swelling should not be warm/hot to touch.
Ice and ibuprofen may help. The affected area must be rested and the patient can expect pain and swelling to start to disperse after 72 hours and last at least 10 days. The painful area must not be massaged.

3) Infection and abscess.
So now to the most serious reason for injection pain. An infection will start in the same manner as tissue irritation with local pain and swelling, with heat and redness around the muscle. The major difference is that after 72 hours tissue irritation should start to subside, if the area is indeed infected this pain and swelling will get worse. The swelling will change in nature becoming more systematic and edema will start to form under the skin becoming softer and more spongy (as described with a lymphatic puncture).

There are many reasons why an infection can manifest, below are some of the most common examples.
Poor injection technique. Correct, and sterile injection technique is a must. You must make sure the injection site and rubber stopper is clean and swabbed with an alcohol wipe.

Also the moisture from the alcohol swab must be allowed to dry before preparing to inject. It is extremely rare but if the alcohol is not allowed to dry the bacterium has not been allowed adequate time to be killed off. If this partly destroyed bacterium was then pushed into a muscle through an Inter-muscular injection the bacterium can “evolve” into a superbug. My wife’s horse died this way due to an impatient vet.

You should always use a clean and new syringe barrel and pin and not allow the pin to touch anything before you inject. Avoid pinning through a hair follicle or hair and don’t be tempted to inject too quickly. Injecting too quickly can increase the risk of infection as this in turn increases injection trauma.

Not rotating injection sites. The risk of infection is massively increased if the same injection site is used over and over again without giving it time to recover. The more an injury (injection trauma) is irritated (re-injected) the more likely it is to become infected. Think back to being a child and picking that scab on your knee excessively and then being told “I told you so” when it becomes a yellow puss infected mess.

Contaminated Gear. This is probably the least common cause of infection with oil based injections (I cannot say the same for water based injections). This is a no brainer really. Use a reputable UGL or pharma and avoid water based suspensions.

What to do in the case of an infection.

So the pain and swelling has not subsided and the edema is pitting and moving outside the confides of the muscle fascia after 72 hours. With an infection the body is attempting to contain the bacterium and prevent it from reaching the circulatory system by forming a cyst. This is essential to prevent blood poisoning. Firstly you need anti-biotics to help the body combat the infection, so it’s off the doctor’s office ASAP. The quicker you start treatment the better chance you have of preventing the cyst growing and leaving a nice big hole in the muscle. The problem here is that the bacterium and infection is contained within a cyst which makes it very difficult for the anti-biotics penetrate.

IMO the single most important thing you can do to ensure a rapid recovery, prevent a creator forming in the infected muscle and avoid a “cut and drain” is to self aspirate the cyst. After 4-5 days of pain and after starting the anti-biotics. Take a syringe barrel at least 1ml larger than the injected volume and a very large gauge pin (18 gauge is ideal). This may hurt but the after effects are well worth it. Directly over the injection site the abscess will be the most swollen part, maybe discolored and will be spongy to touch.

Swab the area very well and slowly penetrate the 18g pin directly into the abscess. Keep pushing the pin in and gentaly aspirating every few millimeters until you hit the cyst. Slowly aspirate the cyst. You should be able to draw out the initial volume injected and then some blood and puss. You can expect to drain out 3ml from a 2ml injection 4-5 days post injection. This will give your immune system and the anti-biotics the best chance of fighting the infection. Always complete the course of anti-biotics even if the symptoms and swelling subside.

I once had a minor abbess probably most likely due to poor injection technique. From that day on I have always had impeccable injection technique. I also suggest having a few 18g pins on standby and anti-biotics in place if this is possible for you.

Proviron - All You Need To Know

Mesterolone is an orally active, 1-methylated DHT. Like Masteron, but then actually delivered in an oral fashion. DHT is the conversion product of testosterone at the 5-alpha-reductase enzyme, the result being a hormone that is 3 to 4 times as androgenic and is structurally incapable of forming estrogen. One would imagine then that mesterolone would be a perfect drug to enhance strength and add small but completely lean gains to the frame. Unfortunately there is a control mechanism for DHT in the human body. When levels get too high, the 3alpha hydroxysteroid dehydrogenase enzyme converts it to a mostly inactive compound known as 3-alpha (5-alpha-androstan-3alpha,17beta-diol), a prohormone if you will. It can equally convert back to DHT by way of the same enzyme when low levels of DHT are detected. But it means that unless one uses ridiculously high amounts, most of what is administered is quite useless at the height of the androgen receptor in muscle tissue and thus mesterolone is not particularly suited, if at all, to promote muscle hypertrophy.

Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.

The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.

Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing “harder” muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders and both actors and models have used it time and again to deliver top shape day in day out, when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.

Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don’t have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.

Mesterolone is generally well liked nonetheless as it delivers very few side-effects in men. In high doses it can cause some virilization symptoms in women. But because of the high level of deactivation and pre-destination in the system (albumin, SHBG, 3bHSD, aromatase) quite a lot of it, if not all simply never reaches the androgen receptor where it would cause anabolic effects, but also side-effects. So its relatively safe. Doses between 25 and 250 mg per day are used with no adverse effects. 50 mg per day is usually sufficient to be effective in each of the four cases we mentioned up above, so going higher really isn’t necessary. Unlike what some suggest or believe,

I will post an abstract to refute these next statements at the bottom of the page

Its not advised that Proviron be used when not used in conjunction with another steroid, as it too is quite suppressive of natural testosterone, leading to all sorts of future complications upon discontinuation. Ranging from loss of libido or erectile dysfunction all the way up to infertility. One would not be aware of such dangers because Proviron fulfills most of the functions of normal levels of testosterone.

Stacking and Use:

Mesterolone is an oral alkylated steroid. If used primarily as an anti-aromatase drug, using it throughout a longer cycle (10-12 weeks) of injectables may elevate liver values a little bit, though much, much less than one would expect with a 17-alpha-alkylated steroid. Eventhough instead of inhibiting gains, mesterolone may actually contribute to gains. So that’s a bit of a shame. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown, but not like 17-alpha alkylation. The reason for the change of position I assume, is because alkylating at the 17-alpha position has been shown to reduce affinity for sex hormone binding proteins. This would in turn decrease its ability to free testosterone. Nonetheless the delivery rate is quite good. Its taken daily in 50-100 mg doses.

The best thing to stack it with is testosterone of course. Its most easily bound to SHBG and albumin, and deactivated for up to 98%. Since the DHT can compete for these structures with higher affinity it would naturally lead to a higher yield of whatever testosterone product you stacked it with. Since DHT levels are notably higher now there is also more stimulation of the androgen receptor causing more strength gains, and because of its affinity for aromatase the overall estrogen level decreases as well. This has as a result that gains are leaner, and once again the overall testosterone yield is increased as less I converted at the aromatase enzyme.

It’s of course used in other stacks with products such as methandrostenolone, boldenone and nandrolone to reduce estrogenic activity and increase muscle hardness. The addition of proviron makes boldenone a dead lock for a cutting stack and for some may even make it possible to use nandrolone while cutting, although the use of Winstrol or a receptor antagonist in conjunction is wishful as well. The benefit of adding it to a nandrolone stack is that it may also help you reduce the decrease in libido suffered from nandrolone, since the latter is mostly deactivated by 5-alpha reductase, an enzyme that makes other hormones more androgenic.

Proviron is an anti-aromatase, so obviously anti-estrogens would be futile and redundant. Blood pressure medication for those prone to hypertension may be wise, as this DHT can increase the blood pressure.

Why Use Bulking Steroids to Bulk?

The answer to this question is: you don’t necessarily need to use bulking steroids to bulk for the reasons previously described. However, there lies plenty of convenience in utilizing bulking steroids that are traditionally very strong compounds, easy to acquire, and relatively inexpensive. Other reasons lie in perhaps the most important and most influential factor: the issue of the more dynamic aspects of the biochemistry rather than the core theory of hormonal action of how they work. What this specifically refers to is the issue of aromatization (the conversion of androgens into Estrogen), and all of the effects that come along with it, such as: water retention, possible fat gain/retention, and the addition of weight in the form of mass that is not muscle (mostly water). Such factors, which exist in almost all bulking steroids can actually be advantageous to an individual looking to bulk up and gain sheer mass and strength without much concern for body fat levels (within reason), or the less aesthetically pleasing effect of increased bloating and water retention.

The effects previously described stem from the result of aromatization, which is the process whereby some anabolic steroids will convert into Estrogen. The aromatization of androgens into Estrogen occurs with various anabolic steroids and not with others. The compounds that undergo moderate to high rates of aromatization tend to be traditionally used as bulking steroids, while those that are immune to aromatization will typically be utilized for other purposes (typically cutting, fat loss, and pre-contest). The aromatization associated with bulking steroids typically result in estrogenic effects such as water retention and non-muscle weight gain. The additional water weight retained by these bulking steroids can be beneficial for strength athletes, weight lifters, and bodybuilders when in bulking phases (or any athletes looking to make a particular weight class), but might be disadvantageous for speed athletes such as sprinters, due to the unnecessary weight gain that might slow them down.

Suffice to say, bodybuilders, strength athletes, and anyone typically looking to ‘bulk up’ represent the core users of bulking steroids. The additional water retention brought upon by the typical bulking steroids can be considered beneficial for many, as it can not only add to the amount of size and weight gained, but can also assist in providing a much fuller look to the muscles, aid in better contractions, and serve as a form of protection as the additional water is retained in and around connective tissue (tendons, joints, ligaments). Such a benefit is of importance to the big and strong heavy lifts that are typically engaged in during a bulk, though it should be noted that bulking steroids will generally provide rapid mass and strength gains that could possibly place excessive strain and stress on connective tissues. Users looking to utilize bulking steroidsshould heed this warning carefully, as a beginner anabolic steroid user engaging in a cycle that includes bulking steroids can possibly gain upwards of 20 – 30 pounds of mass within a matter of weeks, although a large portion of such gains would likely be water weight.

When Bulking Steroids Might Not Be Suitable

Aesthetically, the water gain from the use of bulking steroids might be a problem for those looking to maintain a ‘ripped’ lean physique, as the additional water retention will lend to the physique a soft and puffy look that will blur the definition of the muscles due to peripheral water retention. Hence, this is why competitive bodybuilders tend to utilize bulking steroids during the off-season training, when there is no requirement to achieve peak definition and body fat levels for a stage performance. Additionally, bulking steroids might not be preferable for those who wish to achieve smaller gains, or for those who wish to achieve strictly lean mass gains with minimal to no water or fat retention. Due to the estrogenic nature of bulking steroids, an element of lipogenesis (fat storage) or fat retention might be present. However, for those who wish to eliminate or reduce the incidence of water retention or fat retention/gain, the use of an aromatase inhibitor (such as Aromasin or Arimidex) during the cycle would be optimal. In such a situation, the aromatase inhibitor would inhibit the aromatase enzyme and prevent the anabolic steroid(s) from being aromatized into Estrogen, thereby eliminating water retention and other estrogenic side effects at the root cause. Note that the use of an aromatase inhibitor will do nothing for anabolic steroids that do not aromatize into Estrogen but are estrogenic in and of themselves, such as Anadrol (Oxymetholone).

The following is a list of the typically used and commonly considered bulking steroids (note that not all but most of the following are moderate to highly Estrogenic),

Anadrol (Oxymetholone)
Andriol (Testosterone Undecanoate)
Dianabol (Methandrostenolone)
Deca-Durabolin (Nandrolone Decanoate)
Equipoise (Boldenone Undecylenate)
Sustanon 250 (Testosterone blend)
Testosterone Cypionate
Testosterone Enanthate
Testosterone Propionate
Trenbolone Acetate
Trenbolone Enanthate
Trenbolone Hexahydrobenzylcarbonate (Parabolan)

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Properties of Aromasin

Aromasin (Exemestane) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens classification is the selective estrogen receptor modulators (SERMs), such as Nolvadex and Clomid. AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control.

Properties of Aromasin

Aromasin is extremely effective at 25mg daily for the reduction of serum circulating Estrogen levels in the body, as demonstrated earlier with its ability to reduce Estrogen by 85%. As with other second-line breast cancer treatments, Aromasin is so effective at inhibiting the aromatase enzyme (and thereby reducing Estrogen levels) that this compound is, like Arimidex, only administered to post-menopausal females, and/or utilized when other first-line treatments for breast cancer has failed. This is because post-menopausal females possess a very different shift in hormone levels and endocrine function in comparison to pre-menopausal females.

Arimidex and Letrozole are both classified as non-steroidal and non-suicidal aromatase inhibitors that compete with the substrate for binding to the enzyme active site. This is very different from Aromasin (Exemestane), which is a steroidal and suicidal aromatase inhibitor that acts as a mechanism-based steroidal inhibitor that mimics the substrate, is converted by the enzyme to a reactive intermediate, and results in the inactivation of the aromatase enzyme. For ease of understanding, what this means to the layman is that Aromasin’s chemical structure resembles the traditional ‘targets’ that aromatase binds to (Testosterone, for example) and that it essentially ‘fools’ the aromatase enzyme into binding with it, only to become inhibited/deactivated. Because the binding strength is so great, this inhibition becomes permanent for the aromatase enzyme that Aromasin has become bound to. Arimidex and Letro, being non-suicidal aromatase inhibitors, both compete with the enzyme’s traditional ‘targets’ rather than being assured a permanent spot (which is the advantage that Aromasin has over the other two).

Athletes, bodybuilders, and individuals engaging in the use of anabolic steroidswill favor the use of aromatase inhibitors such as Aromasin for their usefulness in reducing, mitigating, and avoiding Estrogenic side effects. These side effects are result of the aromatazation (or conversion) of aromatizable androgens (such as Testosterone) into Estrogen, which often results in far greater than normal physiological levels of Estrogen in the body. This is where the use of Aromasin (Exemestane) is very beneficial and highly favored among anabolic steroid using individuals, as Aromasin eliminates the issue of rising Estrogen levels at the root cause: By binding to and inhibiting/disabling the aromatase enzyme, supraphysiological levels of aromatizable androgens (such as Testosterone, Dianabol, Boldenone, etc.) cannot convert into Estrogen, thereby eliminating any possible risk of Estrogen-related side effects.

Clenbuterol

Clenbuterol is a bronchodilator designed to treat individuals who suffer from breathing disorders such as chronic asthma. While Clen, as it is commonly called shares some similarities to the popular Ephedrine medication Clenbuterol proves to be far more potent and effective in almost every way; not only as a bronchodilator but as a fat-loss medication as well. While Clenbuterol was developed for breathing disorder treatment it is in its fat-loss abilities for which it is most famous and through the years the use for this purpose has rapidly increased.

The Benefits of Clenbuterol

The benefits of Clenbuterol should be fairly easy to perceive as it will improve cardiovascular efficiency and our metabolic activity. While increasing lipolysis (fat-loss) will prove to be its greatest attribute its benefits do not end there. Clenbuterol has been shown to increase fat-free mass (lean tissue) although not to the degree of an anabolic steroid it will still carry a modest anabolic affect. This increase in fat-free mass, although modest is brought about by an increase in protein synthesis; this simply means your protein, the foundation of muscle tissue, is better served, its activity and efficiency becomes greater than without Clenbuterol being present in the body. Couple this with its strong fat-burning abilities, as increases in muscle tissue also increase metabolic activity you have one very powerful fat reducing medication on your hands.
The Side-Effects of Clenbuterol

As is with all medications, regardless of the form, Clenbuterol is not without the possibility of negative side-effects. While the side-effects will vary from person to person and can be controlled with responsible use they can be quite bothersome and problematic when they show. The most bothersome side-effect is due to this medications stimulating effect; many Clenbuterol users report a very jittery feeling and even insomnia when they take Clenbuterol; however, the extent can be very dose dependent. Another common side-effect is cramping but this appears to be even more individualistic than the jittery effect and can largely be eliminated by ensuring enough water is taken in every day.

There is one side-effect that goes beyond bothersome and into the realm of concern as Clenbuterol can be harsh on the heart through cardiac hypertrophy (the enlargement of ventricles.) However, again, this will be largely dose dependent and of little concern among those who use Clenbuterol responsibly. However, because this is a concern, in order to ensure we use responsibly Clenbuterol is not a medication we would want to use for fat-loss purposes for extended periods of time. We can safely and effectively use this medication for a decent amount of time but there is a right way and a wrong way but either way using this medication for the majority of a year could prove to be very damaging.
Clenbuterol Cycles & Doses:

There are generally two schools of thought on how to best utilize Clenbuterol safely and effectively. The most common method is 2 weeks on followed by two weeks off. While the 2wks on/2wks off is most common, increasingly a steady and longer duration of administration has increasingly become more popular.

    2wks on/2wks off: The idea is simple, start with a low dose and increase it every 2-3 days until you reach your maximum dose desired. Once you’re body begins to adapt discontinue use, wait two weeks and then begin again close to the dose you ended with or even with the exact dose; repeat as many times as necessary.
    Steady Use: Begin with a low dose and increase the dose slightly every 2-3 weeks as needed. Generally the increase will come in spurts of 20mcg and will continue to increase every 2-3 weeks until a desired level of fat-loss is achieved.

As you can see these are two very different methods of application and one emphatically works better than the other. While 2wks on/2wks off is the most popular it is only so due to the vast amount of misinformation thanks to the ever increasing phenomena known as “Bro Science” purported on a host of internet message boards. The truth is simple; the 2wk on/2wk off method is far less efficient than our other option. It is true, after a two week period your body will adjust to the stimulating effect and your jitters will dissipate largely but this does not mean the Clenbuterol is no longer working as is the common misconception. To obtain a full effect, although the immediate fat-loss will be greatest in the first two weeks we must continue Clenbuterol therapy far past the 2 week mark if we are to take full advantage of metabolic increasing activity. To achieve this end a steady increase in Clenbuterol every 2-3 weeks as needed will prove to be far more efficient. Most will find, both men and women that a starting dose of 40mcg per day to be perfect with increases of 20mcg every 2-3 weeks.